Preheat oven to 350 degrees. Line a baking sheet with parchment paper or a silicone baking mat.
Spread almonds and pecans over cookie sheet into an even layer. Toast for 5 minutes, tossing once halfway through. Pour nuts into a large mixing bowl, set aside.
To a small saucepan add butter, sugar, honey, chipotle chili powder, sea salt, chili powder, onion powder and garlic powder and heat mixture over medium heat.
Whisk constantly and bring mixture to a light boil then remove from heat. Immediately pour mixture over nuts and toss to evenly coat then immediately add pretzels and gently toss to evenly coat (before sugar mixture starts to set).
Spread mixture over parchment paper or silicone lined baking sheet and spread into an even layer.
Bake in preheated oven tossing twice during baking and returning to an even layer, about 15 - 20 minutes*.
Let cool completely, while separating nuts and pretzels. Store in an airtight container at room temperature.
Notes
*Nuts should be nicely toasted but not burnt. Sugar mixture will still seem sticky even once it's done, they'll have to cool completely then sugar coating should harden.